Engrailed 2 deficiency and chronic stress alter avoidance and motivation behaviors
Phan ML, Liu TT, Vollbrecht MS, Mansour MH, Nikodijevic I, Jadav N, Patibanda N, Dang J, Shekaran G, Reisler RC, Kim WS, Zhou X, DiCicco-Bloom E & Samuels BA. (2021). Engrailed 2 deficiency and chronic stress alter avoidance and motivation behaviors. Behavioural Brain Research, 113466.
Activation of Basolateral Amygdala to Nucleus Accumbens Projection Neurons Attenuates Chronic Corticosterone-Induced Behavioral Deficits in Male Mice
Dieterich A, Floeder J, Stech K, Lee J, Srivastava P, Barker DJ, & Samuels BA. (2021). Activation of Basolateral Amygdala to Nucleus Accumbens Projection Neurons Attenuates Chronic Corticosterone-Induced Behavioral Deficits in Male Mice. Frontiers in Behavioral Neuroscience, 15, 17.
Chronic non-discriminatory social defeat stress reduces effort-related motivated behaviors in male and female mice
Dieterich A, Liu T, Samuels BA. (2021). Chronic non-discriminatory social defeat stress reduces effort-related motivated behaviors in male and female mice. Translational Psychiatry, 11,125.
Dentate gyrus activin signaling mediates the antidepressant response
Gergues MM, Yohn CN, Bharadia A, Levinstein MR, & Samuels BA. (2021). Dentate gyrus activin signaling mediates the antidepressant response. Translational Psychiatry, 11(1), 1-16.
Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis
Hu P, Maita I, Phan ML, Gu E, Kwok C, Dieterich A, Gergues MM, Yohn CN, Wang Y, Zhou JN, Qi XR, Swaab DF, Pang ZP, Lucassen PJ, Roepke TA, Samuels BA. (2020). Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis. Translational psychiatry, 10(1), 1-17.
Behavioral response to fluoxetine in both female and male mice is modulated by dentate gyrus granule cell activity
Yohn CN, Dieterich A, Maita I, Bazer AS, Diethorn E, Ma D, Gergues MM, Hu P, Samuels BA (2020). Behavioral response to fluoxetine in both female and male mice is modulated by dentate gyrus granule cell activity. Neurobiology of Stress, 13, 100257.
Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice
Dieterich A, Yohn CN, Samuels BA. (2020). Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice. Journal of Visualized Experiments: Jove, (162).
Chronic corticosterone shifts effort-related choice behavior in male mice
Dieterich A, Stech K, Srivastava P, Lee J, Sharif A, Samuels BA. (2020). Chronic corticosterone shifts effort-related choice behavior in male mice. Psychopharmacology, 237(7), 2103-2110.
Perinatal exposure to bisphenol A at the intersection of stress, anxiety, and depression
Wiersielis KR, Samuels BA, Roepke TA. (2020). Perinatal exposure to bisphenol A at the intersection of stress, anxiety, and depression. Neurotoxicology and Teratology, 106884.
Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis
Hu P, Liu J, Maita I, Kwok C, Gu E, Gergues MM, Kelada F, Phan M, Zhou JN, Swaab DF, Pang ZP, Lucassen PJ, Roepke TA, Samuels BA. (2020). Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis. Journal of Neuroscience, 40(12), 2519-2537.
Fluoxetine effects on behavior and adult hippocampal neurogenesis in female C57BL/6J mice across the estrous cycle
Yohn CN, Shifman S, Garino A, Diethorn E, Bokka L, Ashamalla SA, Samuels BA. (2020). Fluoxetine effects on behavior and adult hippocampal neurogenesis in female C57BL/6J mice across the estrous cycle. Psychopharmacology, 1-10.
Chronic corticosterone administration induces negative valence and impairs positive valence behaviors in mice
Dieterich A, Srivastava P, Sharif A, Stech K, Floeder J, Yohn SE, Samuels BA. (2019). Chronic corticosterone administration induces negative valence and impairs positive valence behaviors in mice. Translational psychiatry, 9(1), 1-13.
Chronic non-discriminatory social defeat is an effective chronic stress paradigm for both male and female mice
Yohn CN, Dieterich A, Bazer AS, Maita I, Giedraitis M, Samuels BA. (2019). Chronic non-discriminatory social defeat is an effective chronic stress paradigm for both male and female mice. Neuropsychopharmacology, 44(13), 2220-2229.
Social instability is an effective chronic stress paradigm for both male and female mice
Yohn CN, Ashamalla SA, Bokka L, Gergues MM, Garino A, Samuels BA. (2019). Social instability is an effective chronic stress paradigm for both male and female mice. Neuropharmacology, 160, 107780.
The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor
Samuels BA, Nautiyal KM, Kruegel AC, Levinstein MR, Magalong VM, Gassaway MM, Grinnell SG, Han J, Ansonoff MA, Pintar JE, Javitch JA, Sames D, Hen R. (2017). The behavioral effects of the antidepressant tianeptine require the mu-opioid receptor. Neuropsychopharmacology, 42(10), 2052-2063.
The role of 5-HT receptors in depression
Yohn CN, Gergues MM, Samuels BA. (2017). The role of 5-HT receptors in depression. Molecular brain, 10(1), 1-12.
S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice
Guilloux JP, Samuels BA, Mendez-David I, Hu A, Levinstein M, Faye C, Mekiri M, Mocaer E, Gardier AM, Hen R, Sors A, David DJ. (2017). S 38093, a histamine H 3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Scientific reports, 7, 42946.
Serotonin 1A and Serotonin 4 Receptors: Essential Mediators of the Neurogenic and Behavioral Actions of Antidepressants.
Samuels BA, Mendez-David I, Faye C, David SA, Pierz KA, Gardier AM, Hen R, David DJ. (2016). Serotonin 1A and serotonin 4 receptors: essential mediators of the neurogenic and behavioral actions of antidepressants. The Neuroscientist, 22(1), 26-45.
5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response.
Samuels BA, Anacker C, Hu A, Levinstein MR, Pickenhagen A, Tsetsenis T, Madroñal N, Donaldson ZR, Drew LJ, Dranovsky A, Gross CT, Tanaka KF, Hen R. (2015). 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response. Nature neuroscience, 18(11), 1606.
Hippocampal subfields and major depressive disorder
Samuels BA, Leonardo ED, Hen R. (2015). Hippocampal subfields and major depressive disorder. Biological psychiatry, 77(3), 210.
Mechanisms underlying the antidepressant response and treatment resistance.
Levinstein MR, Samuels BA. (2014). Mechanisms underlying the antidepressant response and treatment resistance. Frontiers in behavioral neuroscience, 8, 208.
Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors.
Samuels BA, Leonardo ED, Dranovsky A, Williams A, Wong E, Nesbitt AM, McCurdy RD, Hen R, Alter M. (2014). Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors. PloS one, 9(1), e85136.
Serotonin receptor expression along the dorsal-ventral axis of mouse hippocampus.
Tanaka KF, Samuels BA, Hen R.. (2012). Serotonin receptor expression along the dorsal–ventral axis of mouse hippocampus. Philosophical Transactions of the Royal Society B: Biological Sciences, 367(1601), 2395-2401.
Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5.
Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH. (2012). Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron, 75(4), 675-687.
Olfactory deficits cause anxiety-like behaviors in mice.
Glinka ME, Samuels BA, Diodato A, Teillon J, Feng Mei D, Shykind BM, Hen R, Fleischmann A. (2012). Olfactory deficits cause anxiety-like behaviors in mice. Journal of Neuroscience, 32(19), 6718-6725.
Modeling treatment-resistant depression.
Samuels BA, Leonardo ED, Gadient R, Williams A, Zhou J, David DJ, Gardier AM, Wong EH, Hen R. (2011). Modeling treatment-resistant depression. Neuropharmacology, 61(3), 408-413.
Neurogenesis and affective disorders.
Samuels BA, Hen R. (2011). Neurogenesis and affective disorders. European Journal of Neuroscience, 33(6), 1152-1159.
Implications of the functional integration of adult-born hippocampal neurons in anxiety-depression disorders.
David DJ, Wang J, Samuels BA, Rainer Q, David I, Gardier AM, Hen R. (2010). Implications of the functional integration of adult-born hippocampal neurons in anxiety-depression disorders. The Neuroscientist, 16(5), 578-591.
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.
Singh KK, Ge X, Mao Y, Drane L, Meletis K, Samuels BA, Tsai LH. (2010). Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron, 67(1), 33-48.
Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.
David DJ, Samuels BA, Rainer Q, Wang JW, Marsteller D, Mendez I, Drew M, Craig DA, Guiard BP, Guilloux JP, Artymyshyn RP, Gardier AM, Gerald C, Antonijevic IA, Leonardo ED, Hen R. (2009). Neurogenesis-dependent and-independent effects of fluoxetine in an animal model of anxiety/depression. Neuron, 62(4), 479-493.
Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth.
Shim SY, Samuels BA, Wang J, Neumayer G, Belzil C, Ayala R, Shi Y, Shi Y, Tsai LH, Nguyen MD. (2008). Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth. Journal of Biological Chemistry, 283(18), 12232-12240.
Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.
Samuels BA, Hsueh YP, Shu T, Liang H, Tseng HC, Hong CJ, Su SC, Volker J, Neve RL, Yue DT, Tsai LH. (2007). Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron, 56(5), 823-837.
Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling–a hypothesis on neuronal migration.
Xie Z, Samuels BA, Tsai LH. (2006). Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling—a hypothesis on neuronal migration. Cerebral cortex, 16(suppl_1), i64-i68.
Nucleokinesis illuminated.
Samuels BA, Tsai LH. (2004). Nucleokinesis illuminated. Nature neuroscience, 7(11), 1169-1170.
Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration.
Xie Z, Sanada K, Samuels BA, Shih H, Tsai LH. (2003). Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell, 114(4), 469-482.
Cdk5 is a dynamo at the synapse.
Samuels BA, Tsai LH. (2003). Cdk5 is a dynamo at the synapse. Nature cell biology, 5(8), 689-690.